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so sunday i broke an arm on my freshly built Remix 5".
i chalked it up to motor desync - it was flying great, did a couple passed and decided to see what top speed was like, brought it around, lined it up, pinned the throttle and instant flip out. it eventually made it to the ground, but not without busting an arm.
i was running it over and over again, and finally realized i never calibrated the ESCs, at low speed it was fine, but the imbalance was more apparent after 80% throttle and the flight controller couldn't compensate.
so, ya, calibrate your ESCs.